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Johnny Moccasin a white teenage boy is raised by an Indian tribe after his parents are killed in a wagon train massacre.
A laconic ex-hired gun in the Old West teams up with three scrappy female prisoners abandoned in the desert, two orphaned children, an army deserter, and a group of cantankerous animals, all of whom try to outsmart and outshoot a ratty gang of desperadoes trying to retrieve their boss' girlfriend and the saddle-tramp's secret cargo.
Just after Carson's gang murder members of a wagon train, Rusty and Clem come along and are arrested. Knowing they are innocent Judge Coleman breaks them out and sends them after Carson. They join Carson's gang to learn of their next raid but the Marshal arrests them for the wagon train murders.
A beautiful young girl is being forced to marry a crooked real-estate agent by making the girl's brother appear to be a thief. Cowboy Nat Sherwood discovers what's going on and sets out to expose the plot.